OBJECTIVE: To evaluate the bone mineral density variability in patients with systemic lupus erythematosus, before the beginning and at 30 and 60 days from the beginning of glucocorticoid therapy. MATERIALS AND METHODS: Fifteen premenopausal women with systemic lupus erythematosus were referred for bone densitometry before being submitted to glucocorticoid therapy. RESULTS: It was demonstrated that the bone mineral density in g/cm² in the lumbar spine presented a significant decrease in the span between the first analysis previously to the beginning of the glucocorticoid therapy and the third analysis after 60 days under therapy. On the other hand no significant difference was found in the femoral neck. CONCLUSION: The authors conclude that, at short term, rather than only at long term as previously reported by other authors, corticotherapy in patients with systemic lupus erythematosus results in a decrease in the bone mineral density in the lumbar spine.

Keywords: Bone densitometry, Premenopause, Systemic lupus erythematosus