Neuro-Behçet’s disease (NBD) is a rare but serious manifestation of Behçet’s disease, categorized into parenchymal and non-parenchymal forms, each with distinct clinical and imaging characteristics. Parenchymal NBD primarily affects the brainstem, basal ganglia, and diencephalon. On magnetic resonance imaging (MRI), acute or subacute lesions appear hyperintense on T2-weighted or fluid-attenuated inversion recovery sequences and isointense to hypointense on T1-weighted sequences, whereas chronic lesions may present as asymmetrical atrophic changes. Non-parenchymal NBD may present as cerebral venous thrombosis, arterial involvement, and meningeal inflammation. Here, we provide a pictorial essay on MRI central nervous system studies, mostly following an international consensus classification of NBD. Although NBD is rare, recognizing its characteristic imaging features is crucial for early diagnosis and treatment, potentially improving prognosis and reducing long-term neurological complications.
Keywords: Behçet syndrome; Magnetic resonance imaging; Vasculitis, central nervous system.