Radiologia Brasileira - Publicação Científica Oficial do Colégio Brasileiro de Radiologia

Dear Editor,

An 11-year-old male patient with asthma that was being treated sporadically presented with dyspnea and acute chest pain. He had no history of recent trauma. Physical examination showed that he was afebrile and tachypneic, with crackles on palpation of the chest, neck, and axillae. A chest X-ray showed pneumomediastinum, together with bilateral subcutaneous emphysema in the soft tissues of the chest and neck (Figures 1A and 1B), findings confirmed by computed tomography (CT) of the chest, which also showed intraspinal air in the posterior aspect of the spine (pneumorrhachis), as depicted in Figure 1C. At 72 h after admission, there was clinical improvement, with a reduction in the extent of the subcutaneous emphysema and significant resorption of the initial pneumomediastinum (Figure 1D). In view of those findings, the patient was diagnosed with Hamman''s syndrome accompanied by pneumorrhachis.




Spontaneous pneumomediastinum, or Hamman''s syndrome, is defined as free air in the mediastinum of no apparent cause, assuming that causes such as trauma, iatrogenic complications, and infections with gas-producing bacteria have been excluded⁽¹⁾. It is usually a benign, self-limiting condition that primarily affects men between 17 and 25 years of age, with an incidence of 1/30,000 hospital admissions⁽²⁾.

The pathophysiology of Hamman''s syndrome is based on the Macklin effect, characterized by alveolar rupture caused by a pressure gradient between the alveoli and the pulmonary interstitium, with the consequent escape of air into the interstitium, the air then flowing toward the pulmonary hilum and mediastinum^(3,4).The main causes of spontaneous pneumomediastinum are intense physical exercise, the labor of childbirth, pulmonary barotrauma, deep dives, severe paroxysmal coughing, vomiting, asthma, a slender body type, the use of narcotics, and intense vocal effort⁽²⁾.

Clinical findings of Hamman''s syndrome include chest pain, dyspnea, neck pain, and subcutaneous emphysema. One characteristic clinical sign, which can be detected on auscultation, is the presence of crackles synchronized with the beating of the heart, known as Hamman''s sign or Hamman''s crunch. Although Hamman''s sign is highly suggestive of the condition, it is present in less than half of all cases⁽⁵⁾. The combination of Hamman''s syndrome and pneumorrhachis is rare and is believed to be attributable to the passage of air through the posterior mediastinum to the neural foramina and epidural space^(6,7).

Chest X-rays are still the gold standard for the diagnosis of Hamman''s syndrome, with a sensitivity close to 100% if posteroanterior and lateral views are obtained⁽²⁾. The main findings include linear images of gas in the mediastinum, typically extending to the neck, together with blisters or large collections of air delineating the mediastinal blood vessels, upper airways, esophagus, or heart. In cases of clinical suspicion of Hamman''s syndrome, CT can be performed if the chest X-ray findings are normal or inconclusive, because it allows the anatomical localization of the air in axial slices and subsequent reconstructions. CT is also the method of choice for the diagnosis and follow-up of pneumorrhachis⁽⁸⁾.

The standard treatment for Hamman''s syndrome is clinical observation combined with supportive measures, usually in a hospital setting. The syndrome typically resolves spontaneously after two to seven days, and recurrence is uncommon⁽⁵⁾.

The prevalence of Hamman''s syndrome is low. Nevertheless, it should be considered in the differential diagnosis of acute chest pain, especially in young patients with subcutaneous emphysema, and the possibility of pneumorrhachis should be investigated.


REFERENCES

1. Kelly S, Hughes S, Nixon S, et al. Spontaneous pneumomediastinum (Hamman''s syndrome). The Surgeon. 2010;8:63-6.

2. Lopes FPL, Marchiori E, Zanetti G, et al. Spontaneous pneumomediastinum following vocal effort: a case report. Radiol Bras. 2010;43:137-9.

3. Murayama S, Gibo S. Spontaneous pneumomediastinum and Macklin effect: overview and appearance on computed tomography. World J Radiol. 2014;6:850-4.

4. Conti-de-Freitas LC, Mano JB, Ricz HMA, et al. A importância da suspeita clínica da síndrome de Hamman na sala de urgência. Rev Bras Cir Cabeça Pescoço. 2009;38:122-3.

5. Fatureto MC, Santos JPV, Goulart PEN, et al. Pneumomediastino espontâneo: asma. Rev Port Pneumol. 2008;14:437-41.

6. Alves GRT, Silva RVA, Corrêa JRM, et al. Pneumomediastino espontâneo (síndrome de Hamman). J Bras Pneumol. 2012;38:404-7.

7. Borem LMA, Stamoulis DNJ, Ramos AFM. A rare case of pneumorrhachis accompanying spontaneous pneumomediastinum. Radiol Bras. 2017;50:345-6.

8. Oertel MF, Korinth MC, Reinges MH, et al. Pathogenesis, diagnosis and management of pneumorrhachis. Eur Spine J. 2006;15 Suppl 5: 636-43.










1. Hospital Santa Teresa, Petrópolis, RJ, Brazil
2. Instituto Estadual do Cérebro Paulo Niemeyer - Departamento de Radiologia, Rio de Janeiro, RJ, Brazil; a. https://orcid.org/0000-0003-1483-2759
3. Instituto Estadual do Cérebro Paulo Niemeyer - Departamento de Radiologia, Rio de Janeiro, RJ, Brazil; b. https://orcid.org/0000-0002-1936-3026

Correspondence:
Dr. Bernardo Carvalho Muniz
Instituto Estadual do Cérebro Paulo Niemeyer – Departamento de Radiologia
Rua do Resende, 156, Centro
Rio de Janeiro, RJ, Brazil, 20231-092
Email: bernardocmuniz@yahoo.com.br

Received August 21, 2017
Accepted after revision September 22, 2017