Radiologia Brasileira - Publicação Científica Oficial do Colégio Brasileiro de Radiologia

INTRODUCTION

Epithelial ovarian tumors correspond to the most lethal malignant neoplasia of the female genital tract. Mucinous and serous tumors are the two most common types of epithelial neoplasia⁽¹⁾. Most commonly, rupture of ovarian cystadenocarcinoma is associated with surgical manipulation⁽²⁾, significantly changing the staging and prognosis of the patients.

Few reports are found in the literature about spontaneous rupture of ovarian cystadenocarcinoma and these reports are mainly regarding pregnant women^(3-5) and patients using anticoagulant drugs⁽⁶⁾. The authors report the first case of spontaneous rupture of ovarian serous cystadenocarcinoma documented by computed tomography both before and after the event.


CASE REPORT

A 54-year-old woman attended the emergency department presenting with sudden-onset dyspnea associated with pain and increased abdominal volume. Chest computed tomography (CT) demonstrated the presence of pulmonary thromboembolism (PTE). Abdominal CT showed a large pelvic solid-cystic mass with gross septations and solid component, compatible with epithelial ovarian tumor (Figure 1).




The patient was admitted for treatment of the PTE, using heparin and, at the ninth day after the admission, she presented a sudden worsening in her condition with abdominal pain and a 3 g/dL drop in hemoglobin levels. A new abdominal CT revealed a voluminous ascites and reduction in the dimensions of the adnexal solid-cystic mass with parietal discontinuity, compatible with spontaneous rupture (Figure 2).




The patient was submitted to exploratory laparotomy that revealed a great amount of hematic ascites and an adnexal tumor with solid component and ruptured cystic area (Figure 3). Anatomopathological analysis characterized high-grade serous carcinoma.




DISCUSSION

The most recent Brazilian population data analysis indicates a risk for ovarian cancer corresponding to 6 cases/ 100,000 women. The main risk factors for development of ovarian cancer include family or personal history of breast or ovarian cancer; post-menopausal hormone replacement therapy, smoking and obesity⁽⁷⁾. Epithelial ovarian tumors correspond to 60% of all ovarian neoplasms and 85% of the malignant ovarian neoplasias⁽¹⁾.

Some of these tumors may present complications such as rupture, torsion, hemorrhage⁽³⁾ or metastasis⁽⁸⁾. Such tumors rupture is frequently reported as occurring intraoperatively in cases where a large lesion is attached to adjacent organs⁽²⁾. Spontaneous rupture rarely occurs, generally as a result either from internal tumor bleeding or from increased intralesional pressure in association with some risk factor^(3,4,6), such as anticoagulant therapies. A previous study reports spontaneous rupture of an ovarian cystadenocarcinoma in a patient with congestive heart failure and undergoing treatment with heparin who progressed with hemoperitoneum, characterized by the presence of hyperdense (65-70 Hounsfield units) fluid in the peritoneal cavity, but without clearly demonstrate the tumor lesion, probably because the scan was performed without using an intravenous contrast agent⁽⁶⁾. In the other cases described in the literature, imaging studies were not performed.

In the present case, the tumor lesion was clearly identified at the initial examination, presenting a sharp change in shape and reduction of dimensions at the subsequent scan, associated with the presence of ascites, which has allowed for establishing the diagnosis of tumor rupture, corroborated by the drop of hemoglobin levels resulting from the use of heparin due to the previous history of PTE. Heparin inhibits the Xa factor and thrombin, blocking the coagulation cascade at these levels with therapeutical purposes; hemorrhage is the main complication⁽⁹⁾. The authors believe that the heparin anticoagulation must have been responsible for a bleeding within the cyst, leading to increased intralesional pressure and subsequent rupture with hemoperitoneum.

Thus, the authors call the attention to the fact that the use of anticoagulant drugs in patients with voluminous cystic lesions must be done cautiously, taking the risk/benefit balance into consideration, with careful follow-up (by ultrasonography, CT or magnetic resonance imaging) along the treatment for evaluation of possible severe complications, like in the present case. Additionally, the extravasation of the cystic content may result in intraperitoneal malignant cells dissemination, modifying the staging, the approach to be adopted and the prognosis of the patient⁽¹⁾.


REFERENCES

1. Jeong YY, Outwater EK, Kang HK. Imaging evaluation of ovarian masses. Radiographics. 2000;20:1445-70.

2. Mizuno M, Kikkawa F, Shibata K, et al. Long-term prognosis of stage I ovarian carcinoma. Prognostic importance of intraoperative rupture. Oncology. 2003;65:29-36.

3. Malhotra N, Sumana G, Singh A, et al. Rupture of a malignant ovarian tumor in pregnancy presenting as acute abdomen. Arch Gynecol Obstet. 2010;281:959-61.

4. Mladenovic-Segedi L, Mandic A, Segedi D, et al. Spontaneous rupture of malignant ovarian cyst in 8-gestation-week pregnancy - a case report and literature review. Arch Oncol. 2011;19:39-41.

5. Daro A, Carey CM, Zummo BP. Spontaneous rupture of a primary carcinoma of the ovary complicating pregnancy. Am J Obstet Gynecol. 1949;57:1011-3.

6. Casal Rodriguez AX, Sanchez Trigo S, Ferreira Gonzalez L, et al. Hemoperitoneum due to spontaneous rupture of ovarian adenocarcinoma. Emerg Radiol. 2011;18:267-9.

7. Brasil. Ministério da Saúde. Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2012: incidência de câncer no Brasil. Rio de Janeiro, RJ: INCA; 2011.

8. Moreira BL, Lima ENP, Bitencourt AGV, et al. Breast metastasis from ovarian carcinoma: a case report and literature review. Radiol Bras. 2012;45:123-5.

9. Staico R, Vaz V, Cesar F, et al. Heparina não-fracionada e de baixo peso molecular: equivalência ou superioridade na intervenção coronária percutânea? Rev Bras Cardiol Invas. 2004;12:138-45.










1. Master, MD, Radiologist, Department of Imaging Diagnosis - Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, SP, Brazil
2. MD, Radiology Residency Preceptor at Hospital da Agro-Indústria do Açúcar e do Álcool de Alagoas, Professor of Imaging Sciences, Universidade Tiradentes (Unit), Maceió, AL, Brazil
3. PhD, MD, Radiologist, Department of Imaging Diagnosis - Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, SP, Associate Professor at Universidade Federal de Alfenas (Unifal), Alfenas, MG, Post-graduation Professor at Universidade do Vale do Sapucai' (Univa's), Pouso Alegre, MG, Brazil
4. Private Docent, Associate Professor, Department of Imaging Diagnosis - Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, SP, Brazil

Mailing Address:
Dra. Priscila Silveira Salvadori
Departamento de Diagnóstico por Imagem - EPM-Unifesp
Rua Napoleão de Barros, 800, Vila Clementino
São Paulo, SP, Brazil, 04024-002
E-mail: pri_ss@hotmail.com

Received June 28, 2013.
Accepted after revision February 14, 2014.

Study developed at Department of Imaging Diagnosis - Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, SP, Brazil.